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. 2018 Feb 15;42(5):285–292. doi: 10.1093/jat/bky007

Figure 2.

Figure 2.

Area-under-the-curve (AUC) oral 100 mg:IV 40 mg and oral 200 mg:IV 40 mg ratios for cocaine (COC) and major metabolites, benzoylecgonine (BZE) and ecgonine methyl ester (EME). AUC ratios for each oral/IV dose were calculated for each participant and averaged to determine dose-proportionality of cocaine and metabolite profile across the three dosing conditions. aAUCs for cocaine and metabolites after 40 mg IV cocaine = 1, bdose-adjusted AUC estimate for 100 mg dose = 2.5-fold higher than IV 40 mg dose, cdose-adjusted AUC estimate for 200-mg dose = 5-fold higher than IV 40 mg dose. Both Cocaine and BZE AUCs were lower than the dose-proportional estimated values. Cocaine AUCs were 0.8 and 2.1 for oral 100 and 200 mg relative to IV 40 mg, and BZE AUCs were 2- and 3.9-fold higher than the IV dose. EME AUCs after oral cocaine exceeded the dose-proportional estimated values, with AUCs after the 100 and 200 mg dose 5.6- and 10.9-fold higher than the IV dose.