Figure 4.
Maximum plasma concentration of cocaine (top), benzoylecgonine (BZE) (middle), and ecgonine methyl ester (EME) (bottom) for females (open bars) and males (solid bars). Top panel: There was a significant effect of sex for cocaine Cmax [F(1,12) = 4.81, P = 0.049], but Tukey comparisons were non-significant when comparing females and males within each of the three dosing conditions, P > 0.05. While sex was not a significant factor, females also displayed higher Cmax values than males for BZE (middle panel) and EME (bottom panel).