. 2018 Feb 15;42(5):285–292. doi: 10.1093/jat/bky007

Table II.

Pharmacokinetic parameters for cocaine and metabolites after oral and intravenous cocaine administration*

Analyte	C _max (ng/mL)	T _max (h)	T _1/2 (h)	AUC (ng h/mL)	V _d (L/kg)	Clearance (mL/[min kg])	AUC ratio metabolite: cocaine
Dose	Mean (SEM) range	Mean (SEM) range	Mean (SEM) range	Mean (SEM) range	Mean (SEM) range	Mean (SEM) range	Mean (SEM) range
COC
IV 40 mg	301 (61.6)^a	0.17 (0.03)^a	1.1 (0.1)^a	306 (32.2)^a	1.3 (0.2)^a	32.7 (2.7)^a	NA
IV 40 mg	111–925	0.05–0.33	0.8–1.5	182–656	0.3–2.5	10.8–53.3	NA
Oral 100 mg	115 (14.7)^b	1.3 (0.1)^b	1.2 (0.1)^b	235 (30.0)^a	4.2 (0.5)^b	116.2 (13.1)^b	NA
Oral 100 mg	45.1–201	0.8–2.0	0.8–1.4	115–448	1.6–7.5	51.5–190.2	NA
Oral 200 mg	268 (33.2)^a	1.3 (0.2)^b	1.3 (0.1)^c	654 (90.0)^b	2.9 (0.5)^c	87.5 (12.9)^b	NA
Oral 200 mg	67.0–570	0.8–3.0	1.0–2.0	151–1,510	1.2–7.6	38.9–221.4	NA
BZE
IV 40 mg	274 (29)^a	2.0 (0.3)^a	6.0 (0.3)^a	2,886 (204)^a	–	–	10.1 (0.8)^a
IV 40 mg	172–614	0.8–4.0	4.7–8.2	2,051–4,604	–	–	5.5–16.2
Oral 100 mg	587 (37)^b	2.0 (0.2)^a	5.8 (0.3)^b	5,782 (441)^b	–	–	27.1 (1.9)^b
Oral 100 mg	353–826	1.0–3.0	4.5–8.2	3,785–9,351	–	–	16.2–38.2
Oral 200 mg	951 (56)^c	3.0 (0.2)^b	6.2 (0.3)^c	11,132 (786)^c	–	–	20.1 (2.4)^c
Oral 200 mg	586–1,296	1.5–4.0	4.8–9.1	6,892–16,453	–	–	8.8–45.9
EME
IV 40 mg	24 (3)^a	1.9 (0.2)	5.4 (0.7)^a	226 (32)^a	–	–	0.8 (0.1)^a
IV 40 mg	7–52	1.0–3.0	2.9–11.7	77–507.1	–	–	0.3–1.3
Oral 100 mg	179 (15)^b	1.9 (0.2)	3.2 (0.2)^b	1,019 (68.2)^b	–	–	5.2 (0.7)^b
Oral 100 mg	122–277	1.0–3.0	2.3–4.5	680.5–1,524	–	–	1.8–9.3
Oral 200 mg	301 (18)^c	2.2 (0.2)^c	3.4 (0.2)^b	1,976 (119.5)^c	–	–	4.3 (1.1)^b
Oral 200 mg	227–408	1.0–4.0	2.6–4.2	1,176–2,930	–	–	1.3–17.4

*Data are typically means of n = 14. There was a dose effect for all listed parameters (except for EME T_max), with P values ranging from <0.0001 to 0.027. Values within each analyte that do not share a letter are significantly different.

COC = Cocaine; BZE = Benzoylecgonine; EME = Ecgonine methyl ester; NA = Not applicable.