Reagent or resource	Source	Identifier
Antibodies
Rabbit monoclonal anti-Phospho-Stat1 (Tyr701)	Cell Signaling Technology	Cat# 7649
Rabbit polyclonal anti-stat1	Cell Signaling Technology	Cat# 9172
Rabbit monoclonal anti-Phospho-IKKα (Ser176)/IKKβ (Ser177)	Cell Signaling Technology	Cat# 2078
Rabbit monoclonal anti-Phospho-IκBα (Ser32)	Cell Signaling Technology	Cat# 2859
Mouse monoclonal anti-IκBα (Amino-terminal Antigen)	Cell Signaling Technology	Cat# 4814
Rabbit monoclonal anti-HIF-1α	Cell Signaling Technology	Cat# 14179
Rabbit monoclonal Anti-Hexokinase II	Cell Signaling Technology	Cat# 2867
Rabbit polyclonal anti-LDHa	Cell Signaling Technology	Cat# 2012
Rabbit monoclonal anti-PKM2	Cell Signaling Technology	Cat# 4053
Rabbit monoclonal anti-Phospho-NF-κB p65 (Ser536)	Cell Signaling Technology	Cat# 3033
Rabbit monoclonal anti-NF-κB p65	Cell Signaling Technology	Cat# 8242
Rabbit monoclonal anti- Phospho-Stat1 (Tyr701)	Thermo Fisher Scientific	Cat# 700349
Rabbit polyclonal anti- iNOS (C-terminal region)	ECM Biosciences	Cat# NP2131
Goat polyclonal anti-mouse IL-1 beta/IL-1F2	R&D systems	Cat# AF-401
Goat polyclonal anti-human IL-1 beta/IL-1F2	R&D systems	Cat# AF-201
Rabbit polyclonal anti-beta Actin	Abcam	Cat# ab8227
Rabbit monoclonal APC/Cy7 anti-mouse CD86	BioLegend	Cat# 105029
GAPDH	Cell Signaling Technology	Cat# 5174
Chemicals, peptides, and recombinant proteins
Lipopolysaccharides from Escherichia coli O127:B8	Sigma-Aldrich	Cat# L4516
Recombinant Murine IFN-γ	PeproTech	Cat# 315-05
Recombinant Murine M-CSF	PeproTech	Cat# 315-02
Recombinant Mouse IFN-beta	R&D systems	Cat# 8234-MB-010
Recombinant Human M-CSF Protein	R&D systems	Cat# 216-MC
Recombinant Human IFN-γ	Peprotech	Cat# 300-02
2-Deoxy-d-glucose	Sigma-Aldrich	Cat# D8375
Lactate Dehydrogenase A Inhibitor, FX11	EMD Millipore	Cat# 427218
d-(+)-Galactose	Sigma-Aldrich	Cat# G0750
d-(+)-Glucose	Sigma-Aldrich	Cat# G8644
Sodium oxamate	Sigma-Aldrich	Cat# O2751
Nω-Nitro-l-arginine methyl ester hydrochloride	Sigma-Aldrich	Cat# N5751
ATP Solution	Thermo Fisher Scientific	Cat# R0441
Adenosine 5′-triphosphate, periodate oxidized sodium salt	Sigma-Aldrich	Cat# A6779
Adenosine 5′-[γ-thio]triphosphate tetralithium salt	Sigma-Aldrich	Cat# A1388
BzATP triethylammonium salt	Abcam	Cat# ab120444
Perchloric acid	Sigma-Aldrich	Cat# 311421
Potassium bicarbonate	Sigma-Aldrich	Cat# 60339
Potassium phosphate monobasic	Sigma-Aldrich	Cat# P5655
Potassium hydroxide	Sigma-Aldrich	Cat# 484016
Tetrabutylammonium hydrogensulfate	Sigma-Aldrich	Cat# 155837
Deuterium oxide	Sigma-Aldrich	Cat# 151882
Oligomycin A	Sigma-Aldrich	Cat# 75351
Oligomycin	Sigma-Aldrich	Cat# O4876
FCCP	Sigma-Aldrich	Cat# C2920
Antimycin A	Sigma-Aldrich	Cat# A8674
Rotenone	Sigma-Aldrich	Cat# R8875
Natural Streptolysin O (Hemolytic streptococcus) protein	Abcam	Cat# ab63978
JAK inhibitor I	EMD Millipore	Cat# 420097
7-AAD Viability Staining Solution	BioLegend	Cat# 420403
MitoSOX™ Red Mitochondrial Superoxide Indicator	Thermo Fisher Scientific	Cat# M36008
Fluoroshield Mounting Medium With DAPI	Abcam	Cat# ab104139
Ficoll-Paque PLUS	GE Healthcare Life Sciences	Cat# 17-1440-03
Critical commercial assays
Proteome Profiler Mouse Cytokine Array Kit	R&D systems	Cat# ARY006
Proteome Profiler Human Cytokine Array Kit	R&D systems	Cat# ARY005B
Avidin/Biotin Blocking Kit	Vector Laboratories	Cat# SP-2001
ATP assay kit	MyBioSource	Cat# MBS841498
Lactate Colorimetric/Fluorometric Assay Kit	BioVision	Cat# K607-100
Deproteinizing Sample Preparation Kit	BioVision	Cat# K808-200
ADP/ATP Ratio Assay Kit	Sigma-Aldrich	Cat# MAK135
Griess Reagent Kit	Thermo Fisher Scientific	Cat# G-7921
XTT Cell Viability Kit	Cell Signaling Technology	Cat# 9095
Deposited data
NMR spectral data
Experimental models: cell lines
RAW 264.7	ATCC	Cat# ATCC® TIB-71™
Human monocytes	Mayo clinic	N/A
Experimental models: organisms/strains
C57BL/6J mice	The Jackson Laboratory	Cat# 000664
Human carotid plaque	Mayo clinic	N/A
Software and algorithms
GraphPad Prism	GraphPad Software (version 7)	https://www.graphpad.com/scientific-software/prism/
BD CellQuest™ Pro (Version 6.0)	BD Biosciences	https://www.bdbiosciences.com/documents/15_cellquest_prosoft_analysis.pdf