Fig. 3. Close-up view of the structure of the artificial Suzukiase 1·S112Y–K121E Sav (pdb code: 5CSE). The solvent-excluded surfaces of two symmetry-related Sav monomers are highlighted in grey and magenta respectively. The biotinylated Pd-cofactor 1 and the mutated residues S112Y and K121E are displayed as stick. No electron density for the cinnamyl-moiety (turquoise) could be detected and was thus modelled, minimizing steric-clashes.