Table 1. Identification of the most suitable ligand for the synthesis of 2-methoxy-1,1′-binaphthyl 8b a .
Entry | Complex | Protein | ee b [%] | TON |
1 | 1 | WT Sav | 58 (R) | 78 |
2 | 2 | WT Sav | 10 (S) | 73 |
3 | 3 | WT Sav | 42 (R) | 45 |
4 | 4 | WT Sav | 6 (R) | 8 |
5 | 5 | WT Sav | rac | <5 |
6 | 1 | WT Avi | 3 (R) | 10 |
aReactions were carried out with 50 mM substrate in a total reaction volume 0.2 mL using 1 mol% complex 1–5 (see ESI for experimental details).
bee value determined by HPLC on a chiral stationary phase; absolute configuration assigned by comparison with literature data. WT = wild-type, Sav = streptavidin, Avi = avidin. All reactions were performed in duplicate: Δee = ±1%, Δconv. = ±5%.