. 2015 Nov 25;7(1):166–182. doi: 10.1039/c5sc03635f

Table 6. Synthesis of FD2 analogs by ClAc ligation ^a .

Compound	Sequence	MS calc./obs.^a	Yield (mg/%)
ClAcD2	(ClCH₂CO–KPL)₄(KKI)₂KHI	2791.64/2791.64	43/17^b
FucC₆G2	(Fuc–O–(CH₂)₆–S–CH₂CO–KPL)₄(KKI)₂KHI	3768.27/3768.27	2.5/31^c
Le^aC₆G2	(Le^a–O–(CH₂)₆–S–CH₂CO–KPL)₄(KKI)₂KHI	5228.80/5228.80	8/63^c

^aOne letter code for amino acids. Branching Lys in italics. The peptide C-terminus is carboxamide CONH₂. ^aMS calc. for [M + H]⁺/MS obs. determined by ESI⁺. Yield is reported for the RP-HPLC purified product after ^bSPPS or ^cClAc ligation.

Table 6. Synthesis of FD2 analogs by ClAc ligation a .

Table 6. Synthesis of FD2 analogs by ClAc ligation ^a .