Skip to main content
. 2015 Nov 25;7(1):166–182. doi: 10.1039/c5sc03635f

Table 8. Activity of FucC6 and Lea glycopeptide dendrimers against Pseudomonas aeruginosa biofilms.

Ligand MBIC a [μM] MBC b [μM] Dispersal MIC c
FD2 20 >30 100% dispersal at 50 μM n.i. d
FucC6G2 9 >20 100% dispersal at 30 μM >64 μM
LeaxG2 30 nd ∼88% dispersal at 50 μM nd

aMBIC is minimal biofilm inhibitory concentration.

bMBC = minimal bactericidal concentration under biofilm forming conditions, determined by CFU counts in the biofilm supernatant.

cMIC = minimal inhibitory concentration in a standard 2-fold dilution assay for antibacterial activity in full LB medium. n.i. = no inhibition in a growth assay using 50 μM compound, nd = not determined.

dFrom ref. 19. See also ESI Fig. S115/S116 (biofilm data), S120 (MIC data), and Table S1 (cell viability data).