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. 2018 May 31;16(2):176–183. doi: 10.9758/cpn.2018.16.2.176

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Copyright © 2018, Korean College of Neuropsychopharmacology

This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 2 — Propofol affects synaptic transmission at parallel fiber-Purkinje cell synapses. (A) Representative traces of parallel fiber evoked excitatory postsynaptic currents (PF-EPSCs) from 0.02% dimethyl sulfoxide (DMSO) and 50 μM propofol at 50μA. (B) Input-output relationship of PF-EPSCs from 0.02% DMSO (open circles, n=8) and 50 μM propofol (closed circles, n=8). (C) Representative traces of PF-EPSCs from 0.1% DMSO and 250 μM propofol at 50μA stimulation. (D) Mean peak amplitudes of PF-EPSCs in 250 μM propofol (closed circles, n=8) were significantly larger compared to 0.1% DMSO (open circles, n=8) over 25μA. Holding potential was −70 mV. Data shown represent the mean± standard error of mean. **p<0.01; paired Student’s t test for DMSO vs. propofol.