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. 2018 May 31;16(2):176–183. doi: 10.9758/cpn.2018.16.2.176

Fig. 3.

Fig. 3

Short-term plasticity is altered in propofol administration at parallel fiber-Purkinje cell synapses. (A) Representative traces of parallel fiber evoked excitatory postsynaptic currents (PF-EPSCs) evoked by paired-pulse stimulation (50 ms interval) in 0.02% dimethyl sulfoxide (DMSO) and 50 μM propofol. (B) Paired-pulse facilitation (PPF) ratios at different interstimulus intervals (10–500 ms) plotted for 0.02% DMSO (open circles, n=9) and 50 μM propofol (closed circles, n=9). (C) Representative traces of PF-EPSCs induced by paired-pulse stimulation (50 ms interval) in 0.1% DMSO and 250 μM propofol. (D) PPF ratios of 250 μM propofol (closed circles, n=8) were significantly smaller compared to 0.1% DMSO (open circles, n=8). The second response is expressed as a percentage of the response to the first pulse and plotted as a function of interstimulus intervals. Data shown represent the mean±standard error of mean. *p< 0.05; **p<0.01; ***p<0.001; paired Student’s t test for DMSO vs. propofol.