Fig. 7.
A schematic diagram illustrating the effect of Cebpd on astrocytic ROS formation and cell death resistance in oxidative stress after AD. In AD, IL-1β activates astrocytic expression of Cebpd, which in turn promotes the expression of NADPH oxidase complex subunits p47phox and p67phox and thus increases the ROS formation of the astrocytes located along the surrounding Aβ area. Simultaneously, Cebpd up-regulates astrocytic expression of Sod1. Expression of Sod1 promotes anti-oxidation in astrocytes, particularly those in the Aβ surrounding area.