Supplemental Table 8.
Echocardiographic results of arrhythmogenic right ventricular cardiomyopathy (ARVC) and control group, 1/3, 2/3, 3/3 novel criteria fulfilled necessary for diagnosis, respectively. All dogs included.
| Parameter | ARVC: 1 of 3 novel criteria | ARVC: 2 of 3 novel criteria | ARVC: 3 of 3 novel criteria | ||||||
|---|---|---|---|---|---|---|---|---|---|
| ARVC (n=88) |
Controls (n=173) |
p-value | ARVC (n=60) |
Controls (n=201) |
p-value | ARVC (n=35) |
Controls (n=226) |
p-value | |
| Decreased RV function | 4 (4.7%) | 1 (0.6%) | 0.032 | 4 (6.9%) | 1 (0.5%) | 0.003 | 4 (11.4%) | 1 (0.5%) | 0.000 |
| RV dilatation | 5 (5.9%) | 4 (2.5%) | 0.184 | 5 (8.6%) | 4 (2.2%) | 0.022 | 4 (11.4%) | 5 (2.4%) | 0.009 |
| RV wall motion abnormality | 5 (5.9%) | 2 (1.3%) | 0.039 | 5 (8.6%) | 2 (1.1%) | 0.003 | 5 (14.3%) | 2 (1.0%) | 0.000 |
| RA dilatation | 4 (4.7%) | 5 (3.1%) | 0.550 | 4 (6.8%) | 5 (2.7%) | 0.145 | 4 (11.4%) | 5 (2.4%) | 0.008 |
| Aortic diameter (mm) | 19.4 ± 3.3 | 19.3 ± 3.0 | 0.857 | 19.5 ± 2.3 | 19.3 ± 3.4 | 0.643 | 19.5 ± 2.3 | 19.3 ± 3.2 | 0.707 |
| LA diameter (mm) | 33.2 ± 9.3 | 30.1 ± 6.8 | 0.010 | 36.4 ± 0.4 | 29.3 ± 6.5 | 0.000 | 37.5 ± 10.4 | 30.1 ± 6.9 | 0.000 |
| LVEF (%) | 45.4 ± 15.7 | 53.1 ± 15.5 | 0.010 | 42.0 ± 16.5 | 53.1 ± 14.0 | 0.000 | 40.6 ± 15.9 | 51.4 ± 15.0 | 0.005 |
| IVSd (mm) | 10.5 ± 1.9 | 10.3 ± 1.9 | 0.545 | 10.6 ± 1.9 | 10.3 ± 1.9 | 0.436 | 10.7 ± 1.9 | 10.4 ± 1.9 | 0.412 |
| LVIDd (mm) | 41.1 ± 8.3 | 38.4 ± 5.9 | 0.009 | 43.3 ± 8.7 | 38.0 ± 5.7 | 0.000 | 43.7 ± 8.2 | 38.8 ± 6.6 | 0.000 |
| LVPWd (mm) | 10.8 ± 1.8 | 10.7 ± 1.8 | 0.766 | 10.7 ± 1.9 | 10.8 ± 1.8 | 0.770 | 10.5 ± 1.7 | 10.8 ± 1.8 | 0.398 |
| LVIDs (mm) | 30.9 ± 9.5 | 27.4 ± 6.9 | 0.004 | 33.5 ± 10.2 | 27.0 ± 6.4 | 0.000 | 34.7 ± 10.4 | 27.7 ± 7.3 | 0.000 |
| FS (%) | 26.5 ± 10.5 | 28.8 ± 9.9 | 0.107 | 24.1 ± 11.0 | 29.4 ± 9.4 | 0.001 | 22.0 ± 10.7 | 29.0 ± 9.7 | 0.000 |
| TAPSE (mm) | 15.2 ± 3.8 | 16.0 ± 2.9 | 0.601 | 15.2 ± 3.9 | 15.8 ± 3.1 | 0.630 | 15.5 ± 4.9 | 15.4 ± 2.9 | 0.934 |
| MV E Velocity (m/s) | 0.84 ± 0.24 | 0.80 ± 0.18 | 0.364 | 0.84 ± 0.26 | 0.81 ± 0.19 | 0.482 | 0.79 ± 0.25 | 0.82 ± 0.20 | 0.586 |
| MV Deceleration time (ms) | 115 ± 35 | 134 ± 38 | 0.035 | 118 ± 30 | 128 ± 40 | 0.348 | 123 ± 38 | 126 ± 38 | 0.798 |
| MV Deceleration slope (m/s2) | 7.0 ± 2.6 | 6.3 ± 2.4 | 0.231 | 6.7 ± 2.5 | 6.6 ± 2.5 | 0.872 | 6.01 ± 2.66 | 6.67 ± 2.48 | 0.512 |
| MV A Velocity (m/s) | 0.55 ± 0.14 | 0.55 ± 0.15 | 0.767 | 0.52 ± 0.14 | 0.56 ± 0.15 | 0.218 | 0.49 ± 0.13 | 0.56 ± 0.15 | 0.057 |
| MV E/A | 1.60 ± 0.75 | 1.54 ± 0.43 | 0.589 | 1.67 ± 0.85 | 1.51 ± 0.44 | 0.156 | 1.74 ± 1.00 | 1.53 ± 0.50 | 0.199 |
| AV Vmax (m/s) | 2.29 ± 1.09 | 2.47 ± 1.27 | 0.342 | 2.03 ± 0.86 | 2.52 ± 1.28 | 0.019 | 1.76 ± 0.54 | 2.50 ± 1.25 | 0.007 |
| AV max PG (mmHg) | 24 ± 29 | 30 ± 32 | 0.246 | 19 ± 20 | 31 ± 33 | 0.032 | 13 ± 10 | 30 ± 33 | 0.015 |
| RVOT PSAX (mm) | 25.0 ± 6.8 | 23.8 ± 4.4 | 0.421 | 25.8 ± 7.0 | 23.6 ± 5.2 | 0.097 | 27.1 ± 6.8 | 23.6 ± 5.6 | 0.016 |
| RVIT 4CH (mm) | 22.8 ± 8.1 | 22.0 ± 3.6 | 0.694 | 23.5 ± 7.7 | 21.5 ± 5.4 | 0.316 | 25.4 ± 9.7 | 21.6 ± 5.1 | 0.108 |
| LVIT 4CH (mm) | 35.1 ± 9.6 | 35.1 ± 5.0 | 0.972 | 36.0 ± 7.2 | 34.4 ± 8.4 | 0.520 | 38.2 ± 6.8 | 34.2 ± 8.0 | 0.158 |
| RVIT/LVIT | 0.67 ± 0.28 | 0.63 ± 0.10 | 0.515 | 0.68 ± 0.31 | 0.63 ± 0.09 | 0.442 | 0.72 ± 0.44 | 0.64 ± 0.09 | 0.282 |
RV: right ventricular; RA: right atrium; LA: left atrium; LVEF: left ventricular ejection fraction; IVSd: intraventricular septum measured in diastole; LVIDd: left ventricular internal diameter in diastole; LVPWd: left ventricular posterior wall measured in diastole; LVIDs: left ventricular internal diameter in systole; FS: fractional shortening; TAPSE: tricuspid annular plane systolic excursion; MV: mitral valve; AV: aortic valve; Vmax: maximal velocity; max PG: maximal pressure gradient; RVOT: right ventricular outflow tract; PLAX: parasternal long axis view, PSAX: parasternal short axis view; RVIT: right ventricular inflow tract; 4CH: four-chamber-view; LVIT: left ventricular inflow tract.