Fig. 7.

Dioscin reversed the effect of miR-140-5p overexpressionin vitro. (A) Effects of dioscin on ROS level in DOX-treated H9C2 cells with transfection of miR- 140-5p mimic. (B) Effects of miR-140-5p mimic on the expression levels of Nrf2 and Sirt2 in H9C2 cells. ^**p < 0.01, compared with control groups. (C) Effects of dioscin on the expression level of Nrf2 and Sirt2 in DOX -treated H9C2 cells with transfection of miR-140-5p mimic. All data are expressed as the mean ± SD (n = 5). ^**p < 0.01, compared with DOX group or DOX + mimic group.