. 2015 Nov 10;1(4):174–178. doi: 10.1515/jccm-2015-0026

Table 1.

Hunter serotonin toxicity criteria — decision rules [4]

Hunter Serotonin Toxicity Criteria: Decision Rules
In the presence of a serotonergic agent:

1 IF (spontaneous clonus = yes) THEN serotonin toxicity = YES

2 ELSE IF (inducible clonus = yes) AND [(agitation = yes) OR (diaphoresis = yes)] THEN serotonic toxicity = YES

3 ELSE IF (ocular clonus = yes) AND [(agitation = yes) OR (diaphoresis = yes)] THEN serotonic toxicity = YES

4 ELSE IF (tremor = yes) AND (hyperreflexia = yes) THEN serotonin toxicity = YES

5 ELSE IF (hypertonic = yes) AND (temperature>380C) AND [(ocular clonus = yes) OR (inducible clonus = yes)] then serotonin toxicity = YES

6 ELSE serotonin toxicity = NO