Table 4.
Summary of findings table: the three most important patients outcomes are listed in the summary of findings table.
| 4.1 EIH vs. Antihypertensive drugs | |||||
|---|---|---|---|---|---|
| Patients or population: patients with essential hypertension | |||||
| Settings: in adult patients | |||||
| Intervention: EIH | |||||
| Outcomes | Illustrative comparative risks* (95% CI) | No of Participants (studies) | Quality of the evidence (GRADE) | Comments | |
| Assumed risk control | Corresponding risk EIH | ||||
| Systolic blood pressure | The mean systolic blood pressure ranged across control groups from 134.24 to 151.2 mmHg | The mean systolic blood pressure in the intervention groups was 0 higher (2.3 lower to 1.43 higher) | 606(5 studies) | ⊕⊕⊖⊖low | |
| Diastolic blood pressure | The mean distolic blood pressure ranged across control groups from 84.4 to 92.4 mmHg | The mean diastolic blood pressure in the intervention groups was 0.02 lower(1.13 lower to 1.09 higher) | 606(5 studies) | ⊕⊕⊖⊖low | |
| Left ventricular mass index | The mean left ventricular mass index ranged across control groups from 91.41 to 122.2 g/m2 | The mean left ventricular mass index in the intervention groups was 1.36 lower(4.99 lower to 2.26 higher) | 85(2 studies) | ⊕⊕⊖⊖low | |
| 4.2 EIH plus Antihypertensive drugs vs. Antihypertensive drugs | |||||
| Patients or population: patients with essential hypertension | |||||
| Settings: in adult patients | |||||
| Intervention: EIH plus Antihypertensive drugs | |||||
| Systolic blood pressure | The mean systolic blood pressure of the control group in single study was 131.8 mmHg | The mean systolic blood pressure in the intervention group was 8.5 lower(11.99 to 5.01 lower) | 166(1 study) | ⊕⊕⊖⊖low | |
| Diastolic blood pressure | The mean diastolic blood pressure of the control group in single study was 82.5 mmHg | The mean diastolic blood pressure in the intervention group was 8.7 lower(11.49 to 5.91 lower) | 166(1 study) | ⊕⊕⊖⊖low | |
| GRADE Working Group grades of evidence | |||||
| High quality: Further research is very unlikely to change our confidence in the estimate of effect. | |||||
| Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate. | |||||
| Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate. | |||||
| Very low quality: We are very uncertain about the estimate. | |||||
*
The basis for the assumed risk (e.g., the median control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI).
CI: Confidence interval.