Incidence on y-axis (per 100,000) and year of diagnosis on x-axis. Blue, green, red, and grey indicate respective races: Whites, Blacks, Hispanic and Asian. In Figure 4A, in zero joinpoint model non-significant changes in OPSCC incidence were seen for ages 40-49, and 80+ (p>0.114 for each). Incidence of OPSCC increased significantly in the study period for 50-59 (APC 2.5, p<0.001), 60-69 (APC 2.7, p<0.001), and 70-79 (APC 1.6, p<0.001) year old men. In joinpoint analysis, significant increases for 60-69 year old men were observed 1999-2014 (APC 3.8, p<0.001) and for 70-79 year old men during 1992-1998 (APC 4.8, p=0.02) and 2001-2014 (APC 4.2, p<0.001). In Figure 4B, in selected joinpoint models, OPSCC incidence increased for Whites during 1999-2014 (APC 3.5, p<0.001) and Hispanics during 2006-2014 (APC 5.6, p=0.003), while decreasing for Blacks during 1992-2014 (APC-1.9, p<0.001). In Figure 4C, incidence rates for non-OP HNSCC are shown in zero joinpoint model. There were significant decreases for Whites (APC -1.7, p<0.001), Blacks (APC -3.4, p<0.001), Hispanics (APC -1.7, p<0.001), and Asians (APC -1.6, p<0.001). In joinpoint modeling, significant declines in incidence for Whites were noted during 1992-2003 (APC -2.8, p<0.001) and 2003-2014 (APC -0.7, p=0.002) and for Asians during 1996-2006 (APC -3.6, p<0.001). Incidence rates are age-adjusted to the 2000 US Standard Population (19 age groups – Census P25-1130).