Table 1.
Genes associated with retinoid homeostasis and stellate cell activation
| Fold change upper versus | GVAD-HFD | GVAD-LF12 |
|---|---|---|
| lower | BD-HFD | LF12-LF12 |
| Retinoid Homeostasis | ||
| Cyp26a1 | -26.5** | -28.4** |
| Cyp26b1 | -4.8** | -78.1** |
| Lrat | -2.2** | -22.1** |
| Rbpr2 | -1.4** | n.s. |
| Stra6 | n.s | n.s. |
| Rbp4 | 1.8** | n.s. |
| Rbp1 (Crbp1) | 3.2** | -5.3** |
| Stellate Cell Activation | ||
| Acta2 (Sma) | 1.7* | -2.7* |
| Col1a1 | 4.6** | -14.0** |
| Col1a2 | 1.9** | -6.4** |
| Col3a1 | 2.8** | -9.9** |
| Col4a1 | 2.1** | -1.7 |
| Col4a5 | 2.1** | n.s. |
| Col5a1 | 1.6** | -2.8** |
| Col5a2 | 2.9** | -3.8** |
| Col6a1 | 2.0** | -3.6** |
| Mmp13 | 1.9** | -3.8** |
| Mmp3 | 4.0** | n.s. |
| Smpd3 | 3.1** | -3.3** |
| Timp2 | 1.7** | -1.8** |
| Timp3 | 2.6** | -2.1* |
| Cyp1b1 | 2.9** | -2.9** |
*
p-value ≤ 0.05
**
p-value ≤ 0.01
n.s. Non-significant values where the net FC < 1.5 and p-value > 0.05