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. 2018 May 15;13(5):e0196976. doi: 10.1371/journal.pone.0196976

Fig 7. Effects of the endothelial targeted AbVCAM-1 dexamethasone SAINT-O-Somes in liver of double LPS challenged mice.

Fig 7

mRNA expression of pro-inflammatory molecules (cell adhesion molecules and cytokines), vascular integrity related molecules (Tie2, CD31, VE-cadherin, Ang2), blood flow-sensitive transcription factor KLF2 in the liver was determined by real time RT-PCR using GAPDH as housekeeping gene. All data are presented as mRNA level relative to GAPDH. Values are shown as mean ± SD of each group (n = 6). *, P<0.05, free dexamethasone vs. 2xLPS; #, P<0.05, anti-VCAM-1 respectively IgG dexamethasone SAINT-O-Somes vs. 2xLPS.