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. 2018 May 15;13(5):e0196272. doi: 10.1371/journal.pone.0196272

Table 2. The results of Analysis I for individual and group interventions for each outcome.

Individual Group
Outcome p-value SMD (95%CI) I2(%) p-value SMD (95%CI) I2(%)
Primary outcome Autism general symptoms 0.28 −0.31[−0.63, 0.01] 21 N/A
Secondary outcomes Developmental quotient 0.02* 0.36[0.05, 0.66] 20 N/A
Developmental quotient (baseline imbalance-adjusted) 0.07 0.31[−0.02, 0.65] 26 N/A
Expressive language 0.18 0.13[−0.06, 0.33] 0 0.92 0.11[−0.07, 0.30] N/A
Expressive language (baseline imbalance-adjusted) 0.18 0.13[−0.06, 0.33] 0 N/A
Receptive language 0.19 0.17[−0.09, 0.42] 28 0.59 −0.14[−0.65, 0.37] N/A
Reciprocity of social interaction towards others p<0.001*** 0.59[0.25, 0.93] 18 0.04* 0.45[0.02, 0.88] 18
Adaptive behaviour 0.60 −0.05[−0.25, 0.14] 39 0.47 0.44[−0.77, 1.65] N/A
Other outcomes Qualitative impairment in social interaction 0.61 −0.15[−0.40, 0.10] 0 N/A
Qualitative impairment in communication 0.85 −0.03[−0.35, 0.29] N/A N/A
Restricted repetitive and stereotyped patterns of behaviour, interests and activities 0.17 −0.21[−0.52, 0.09] 39 N/A
Initiating joint attention 0.13 0.48[−0.14, 1.10] 78 0.57 0.15[−0.38, 0.68] 15
Responding to joint attention 0.11 0.63[−0.14, 1.39] 97 N/A
Imitation 0.11 0.54[−0.25, 1.33] 62 N/A
Parental synchrony p<0.001*** 0.99[0.70, 1.29] 0 N/A
Parenting stress 0.35 −0.30[−0.93, 0.32] 0 0.27 −0.29[−0.81, 0.22] 0

“p-value” indicates value of the test of overall synthesis. SMD indicates standard mean difference of the synthesised effect. 95% CI indicates 95% confidence interval of the SMD of the overall synthesis.

* and *** indicate statistically significant effects (p < 0.05, p < 0.01, and p < 0.001, respectively) in the analysis.

N/A indicates data synthesis could not be performed due to lack of available studies.

“baseline imbalance-adjusted” indicates results of the analysis after excluding the studies with baseline imbalances.