Fig 4. CD56^dim NK cells are more effective than CD56^bright NK cells at supporting VZV infection.

(A) Healthy human donor PBMCs were infected with VZV for 2 days then analysed for infection by flow cytometry. Plots show gating strategy for CD56^bright and CD56^dim NK cells (CD3^–CD56⁺) (left panel), with respective surface VZV gE:gI expression (right panels) from one representative donor (n = >7). (B & C) CD3^–CD56^bright (B) and CD3^–CD56^dim (C) NK cells were isolated from healthy human donor PBMCs by FACS sorting and subsequently infected with VZV for 2 days before analysis by flow cytometry. Plots show surface gE:gI expression from one representative donor (n = 2).