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. 2018 May 3;14(5):e1007366. doi: 10.1371/journal.pgen.1007366

Fig 1. Deletion of CnB1 in keratinocytes enhances the skin acute inflammatory response to TPA treatment and to UVB exposure.

Fig 1

A. Ear thickness was measured at different time points as indicated. ## p<0.01 when comparing the TPA-treated group with the untreated group, ** p<0.01 when comparing the CnB1-/- (KO) group (KO+TPA) with the control CnB1+/+ group (Ctrl+TPA); B. Histological analysis of ears of Ctrl and KO mice at 48 hr after TPA treatment; C. Thickness of dorsal skin collected at the indicated time points was measured using a microscope. ## p<0.01 when comparing the UVB-exposed group with the untreated group, ** p<0.01 when comparing the KO group (KO+UVB) with the control group (Ctrl+UVB); D. Histological analysis of dorsal skins of Ctrl and KO mice at 48 hr after exposure to UVB; E-H. Sections from C and D were analyzed for infiltration of inflammatory cells by IF analysis of Gr-1 (E, green) and F4/80 (G, green), DAPI is used as a counter-stain for nuclei. The corresponding quantification analysis of E and G is shown in F (Gr-1) and H (F4/80). * p<0.05 when comparing the data indicated with the brackets. Bars = 500 μm for B, D; 100 μm for E, G. Student’s t test analysis was used for all quantification data to compare two groups as indicated, n = 3, Standard error bars are provided in A, C, F and H.