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. Author manuscript; available in PMC: 2019 Jan 1.
Published in final edited form as: Lancet Diabetes Endocrinol. 2017 Nov 9;6(1):51–59. doi: 10.1016/S2213-8587(17)30367-4

Figure 3. Standardized Cumulative Incidence Curve of Composite Cardiovascular Events in Medically Treated Primary Aldosteronism Stratified by Plasma Renin Activity Achieved with Mineralocorticoid Receptor Antagonists and Essential Hypertension.

Figure 3

Solid lines = adjusted cumulative incidence; dashed lines = unadjusted cumulative incidence.

Incident composite cardiovascular events defined as a composite of incident myocardial infarction/coronary revascularization, congestive heart failure hospitalization, and transient ischemic attack/cerebrovascular accident. PA = primary aldosteronism; PRA = plasma renin activity; MR = mineralocorticoid receptor.

a Hazard ratios adjusted for, and cumulative incidence curve standardized to the distribution of, the following variables at the time of study entry in our cohort: age, sex, race/ethnicity, BMI, smoking status, diabetes mellitus, hemoglobin A1C, atrial fibrillation, LDL cholesterol, statin use, daily aspirin use, estimated glomerular filtration rate, systolic blood pressure, diastolic blood pressure, and number of antihypertensive medications.