Table 2. Adjusted Incidence Rate Ratios (aIRR) for uncomplicated malaria and non-malarial diseases in Kenya by Sl and McC genotype*.

Clinical Outcomes	Sl2 aIRRs† (95% CI)	P value	McCb aIRRs (95% CI)	P value
Uncomplicated malaria	0.49 (0.34–0.72)‡	<0.001 4	1.24 (0.90–1.70)	0.184 1
All non-malaria clinical visits	1.13 (0.96–1.32)	0.140 1	0.76 (0.61–0.96)‡	0.020 4
LRTI§	1.09 (0.81–1.47)	0.561 1	0.39 (0.16–0.96)	0.040 1
URTI#	1.21 (0.98–1.50)	0.073 1	0.79 (0.63–0.99)	0.047 3
Gastroenteritis	0.66 (0.43–1.03)	0.066 2	0.55 (0.31–0.97)‡	0.038 2
Skin infection	1.33 (0.79–2.26)	0.285 2	0.42 (0.16–1.13)	0.086 1
Helminth infection	1.98 (0.83–4.71)	0.122 2	0.68 (0.43–1.07)	0.094 4
Malaria negative fever	0.83 (0.58–1.18)	0.293 2	1.03 (0.80–1.33)	0.828 3

*Data were collected from 22 Sl1/Sl1, 94 Sl1/Sl2 and 92 Sl2/Sl2 individuals during 49.4, 213.8 and 188.8 cyfu (child-years of follow-up), respectively, and 137 McC^a/McC^a, 63 McC^a/McC^b and 8 McC^b/McC^b individuals during 294.5, 143.2 and 14.3 cyfu, respectively. Both Sl2 and McC^b alleles were tested for their association with the disease outcomes of interest using Poisson regression in the ¹recessive, ²dominant, ³heterozygous and ⁴additive models. The best fitting models as examined using the Akaike information criterion (AIC) were used in the final analysis that included adjustment for McC genotype (for Sl analyses), Sl genotype (for McC analyses) α⁺thalassaemia and sickle cell genotype, ABO blood group, season (divided into 3 monthly blocks), ethnicity, age as a continuous variable and within-person clustering of events.

^†aIRRs: adjusted Incidence Rate Ratios.

^‡Models that showed significant evidence of interaction between either Sl2 or McC^b and α⁺thalassaemia.

^§LRTI: Lower Respiratory Tract Infection.

^#URTI: Upper Respiratory Tract Infection.