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. Author manuscript; available in PMC: 2018 Jul 1.
Published in final edited form as: Environ Sci Pollut Res Int. 2017 Nov 15;25(17):16493–16507. doi: 10.1007/s11356-017-0149-1

Fig. 3.

Fig. 3

Differentially expressed genes in the important cancer-relevant signaling pathways and their connectivity in the 45-month-old PCB exposed population in Slovakia, showing genes with significant effects on expression levels (with ≥ 1.5-fold change, t test, p < 0.05) with some downstream effects, e.g., DNA repair, DNA fragmentation, chromatin condensation, cell shrinkage & membrane blebbing, caspase-independent DNA fragmentation, and apoptosis. Geometric figures in red denote up-regulated genes and those in green indicate down-regulation. Canonical pathways (functions/signaling; CP) viz., p53 signaling, prostate cancer signaling, NF-kB signaling, G-protein coupled receptor signaling, endometrial cancer signaling, ovarian cancer signaling, cell cycle: G2/M DNA damage checkpoint regulation, p38 MAPK signaling, and aryl hydrocarbon receptor signaling that are highly represented are shown within the box. Genes in uncolored notes were not identified as differentially expressed in our experiment