Table 3.
Cause-specific hazard ratios and 95% confidence intervals for factors associated with change to a second-line ART regimen or attrition in a competing risk analysis
| Factor n = 4,120 |
Univariate | Multivariate | ||||
|---|---|---|---|---|---|---|
|
|
|
|||||
| HR | 95% CI | P value | aHR | 95% CI | P value | |
| Change to Second-line ART | ||||||
| Sex | ||||||
| Female | Ref | Ref | ||||
| Male | 1.287 | 1.133 – 1.463 | <0.001 | 1.317 | 1.147 – 1.513 | <0.001 |
| Age per year | 1.089 | 1.069 – 1.110 | <0.001 | 1.043 | 1.020 – 1.067 | <0.001 |
| WAZ per sd | 0.971 | 0.938 – 1.006 | 0.101 | 0.999 | 0.961 – 1.039 | 0.969 |
| CD4 count per 50 cells/µl | 0.925 | 0.911 – 0.937 | <0.001 | 0.930 | 0.9176 – 0.946 | <0.001 |
| WHO per stage | 0.990 | 0.858 – 1.143 | 0.895 | 0.969 | 0.818 – 1.126 | 0.613 |
| Regimen | ||||||
| NNRTI | Ref | Ref | ||||
| PI | 0.387 | 0.260 – 0.576 | <0.001 | 0.355 | 0.221 – 0.572 | <0.001 |
| Clinic Type | ||||||
| Public | Ref | Ref | ||||
| Academic | 0.632 | 0.510 – 0.783 | <0.001 | 0.354 | 0.254 – 0.494 | <0.001 |
| Non-profit/Private | 1.149 | 0.964 – 1.369 | 0.121 | 0.839 | 0.594 – 1.186 | 0.321 |
| Clinic Location | ||||||
| Urban | Ref | Ref | ||||
| Rural | 0.553 | 0.361 – 0.847 | 0.006 | 0.709 | 0.443 – 1.136 | 0.152 |
| In-between | 0.889 | 0.780 – 1.012 | 0.076 | 0.839 | 0.705 – 0.997 | 0.046 |
| Clinic Type | ||||||
| Children only | Ref | Ref | ||||
| Family Clinic | 0.720 | 0.627 – 0.827 | <0.001 | 0.521 | 0.375 – 0.725 | <0.001 |
| Clinic Started Providing ART | ||||||
| Before 2004 | Ref | Ref | ||||
| 2004 or after | 0.782 | 0.687 – 0.891 | <0.001 | 1.009 | 0.826 – 1.231 | 0.932 |
| VL Availability | ||||||
| None | Ref | Ref | ||||
| Confirmatory | 1.321 | 0.825 – 2.118 | 0.244 | 1.767 | 0.687 – 1.274 | 0.040 |
| Routine | 1.851 | 1.150 – 2.964 | 0.010 | 1.604 | 0.886 – 2.902 | 0.119 |
| Death/ Lost to Program | ||||||
| Sex | ||||||
| Female | Ref | Ref | ||||
| Male | 1.042 | 0.908 – 1.194 | 0.563 | 1.049 | 0.901 – 1.221 | 0.539 |
| Age per year | 1.024 | 1.003 – 1.044 | 0.023 | 0.996 | 0.970 – 1.020 | 0.732 |
| WAZ per sd | 0.907 | 0.874 – 0.941 | <0.001 | 0.921 | 0.885 – 0.959 | <0.001 |
| CD4 count per 50 cells/µl | 0.979 | 0.968 – 0.990 | <0.001 | 0.977 | 0.963 – 0.989 | 0.001 |
| WHO per stage | 0.980 | 0.836–1.149 | 0.803 | 0.900 | 0.756 – 1.071 | 0.236 |
| Regimen | ||||||
| NNRTI | Ref | Ref | ||||
| PI | 0.923 | 0.691 – 1.232 | 0.585 | 0.842 | 0.587 – 1.208 | 0.351 |
| Clinic Type | ||||||
| Public | Ref | Ref | ||||
| Academic | 0.799 | 0.642 – 0.995 | 0.045 | 0.532 | 0.374 – 0.757 | <0.001 |
| Non-profit/Private | 1.685 | 1.419 – 2.002 | <0.001 | 1.447 | 1.033 – 2.029 | 0.032 |
| Clinic Location | ||||||
| Urban | Ref | Ref | ||||
| Rural | 0.695 | 0.453 – 1.067 | 0.096 | 0.714 | 0.439 – 1.161 | 0.175 |
| In-between | 1.010 | 0.877 – 1.162 | 0.893 | 0.747 | 0.614 – 0.910 | 0.004 |
| Clinic Type | ||||||
| Children only | Ref | Ref | ||||
| Family Clinic | 0.766 | 0.659 – 0.890 | <0.001 | 0.714 | 0.494 – 0.942 | 0.039 |
| Clinic Started Providing ART | ||||||
| Before 2004 | Ref | Ref | ||||
| 2004 or after | 0.764 | 0.663 – 0.880 | <0.001 | 0.921 | 0.695 – 1.115 | 0.487 |
| VL Availability | ||||||
| None | Ref | Ref | ||||
| Confirmatory | 0.805 | 0.549 – 1.179 | 0.265 | 0.828 | 0.541 – 1.267 | 0.385 |
| Routine | 0.835 | 0.568 – 1.228 | 0.360 | 0.624 | 0.379 – 1.027 | 0.064 |