Table 4.

HIV-1 subtype B and C levels of neprilysin, ratios and indexes in cerebrospinal and serum.

Biomarker	HIV1-B	HIV1-C	Diff (95% CI)	pa	pb
CSF (n)	27	26
NEP	1.20 (0.17)	1.17 (0.17)	0.21(−0.33, 0.75)	0.99	0.99
NEP/Aβ-38	−2.11 (0.25)	−2.09 (0.26)	−0.07(−0.61, 0.47)	0.36	0.45
NEP/Aβ-40	−2.43 (0.23)	−2.41 (0.22)	−0.08 (−0.62, 0.46)	0.31	0.45
NEP/Aβ-42	−1.47 (0.26)	−1.42 (0.23)	−0.21(−0.75, 0.33)	0.17	0.45
NEP/Aβ-total	−2.63 (0.23)	−2.61 (0.23)	−0.09 (−0.62, 0.45)	0.31	0.45
Serum (n)	21	26
NEP	2.43 (0.32)	2.30 (0.16)	0.5 (−0.05, 1.04)	0.060	0.083
NEP/Aβ-38	1.50 (0.78)	1.42 (0.58)	0.15 (−0.39, 0.69)	0.63	0.63
NEP/Aβ-40	0.54 (0.52)	0.31 (0.25)	0.56 (0.01, 1.11)	0.032	0.083
NEP/Aβ-42	1.82 (0.56)	1.60 (0.30)	0.5 (−0.05, 1.05)	0.067	0.083
NEP/Aβ-total	0.45 (0.55)	0.23 (0.27)	0.5 (−0.04, 1.05)	0.055	0.083
CSF/Serum
NEP	−1.23 (0.33)	−1.13 (0.26)	−0.33 (−0.87, 0.22)	0.12	0.15
NEP/Aβ-38	−3.66 (0.79)	−3.51 (0.68)	−0.20 (−0.74, 0.34)	0.41	0.41
NEP/Aβ-40	−2.99 (0.51)	−2.72 (0.34)	−0.63 (−1.18, −0.07)	0.008	0.021
NEP/Aβ-42	−3.32 (0.53)	−3.01 (0.30)	−0.7 (−1.25, −0.14)	0.005	0.021
NEP/Aβ-total	−3.11 (0.54)	−2.84 (0.36)	−0.57 (−1.12, −0.02)	0.017	0.021
NEP Indexc	0.90 (0.43)	1.02 (0.49)	−0.26 (−0.86, 0.35)	0.22	0.22

Values were log10-transformed and presented in mean (SD); Diff: Group differences presented as Cohen’s d; CI: confidence interval.

^ap adjusted for plasma VL suppression and CD4 nadir count

^bp adjusted for plasma VL suppresion and CD4 nadir count, corrected for multiple testing with the Benjamini-Hochberg (BH) method. Significant differences are in bold typeface.

^cNEP_Index=(NEP_CSF × Alb_serum)/(NEP_serum × Alb_CSF)