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. Author manuscript; available in PMC: 2019 Jun 1.
Published in final edited form as: Crit Care Med. 2018 Jun;46(6):e600–e608. doi: 10.1097/CCM.0000000000003077

Figure 3. Midazolam induces loss of memory in wildtype mice.

Figure 3

Wildtype (C57BL6/J) were injected with either midazolam (10 mg/kg i.p.), LPS (100 μg/kg i.p.) or midazolam and LPS and compared to saline treated controls. 24 or 27 hours later mice underwent behavioral studies using novel-object-recognition tests. (A) Preference in % for a novel object after 2 days habituation to two old objects 24 hours after a single dose of saline in wildtype mice. (B) Preference in % for a novel object after 2 days habituation to two old objects 24 or 72 hours after a single dose of midazolam in wildtype mice. (C) Preference in % for a novel object after 2 days habituation to two old objects 24 or 72 hours after a single dose of LPS in wildtype mice. (D) Preference in % for a novel object after 2 days habituation to two old objects 24 or 72 hours after a single dose of LPS + midazolam in wildtype mice. All data have n=5 individual animals and are presented as mean ± SD, LPS=Lipopolysaccharide, P value denotes t-test (see also Supplemental Digital Content 1).