Table 3.
Comparison of PBMC cytokine production after 24 hours of stimulation with TLR-4 agonist between ASDNOGI, ASDGI and TDNOGI. Data presented as median and interquartile ranges.
| TLR4 (LPS) | |||
|---|---|---|---|
| ASDNOGI Median (IQR) |
ASDGI Median (IQR) |
TDNOGI Median (IQR) |
|
| IL-1α | 3,959‡* (3,615-4,376) |
3,160 (1,602-4,036) |
2,660 (1,115-3,913) |
| IL-1β | 12,506‡ (9,304-17,562) |
10,727 (7,888-15,632) |
9,782 (6,370-12,298) |
| IL-6 | 35,049 (26,923-46,236) |
33,143 (20,277-41,781) |
31,468 (21,858-47,848) |
| IL-12p40 | 43.69 (19.39-75.11) |
39.28 (19.39-96.25) |
57.64 (36.21-75.11) |
| IL-12p70 | 5.35‡ (3.34-7.46) |
7.46 (3.588-9.65) |
7.63 (5.35-9.65) |
| TNFα | 4,072‡ (2,904-5,139) |
4,084 (2,765-5,959) |
3,071 (2,074-3,989) |
| IFNγ | 159.90 (53.63-293.20) |
253.50 (85.24-878) |
168.90 (75.51-288.20) |
| IL-4 | 2.25 (2.25-4.16) |
2.25 (2.25-11.13) |
2.25 (2.25-11.13) |
| IL-13 | 19.50 (13.48-28.99) |
20.80 (15.14-30.88) |
19.50 (14.16-24.65) |
| IL-10 | 9,253 (4,421-10,885) |
6,151 (3,007-10,047) |
6,048 (3,904-8,017) |
| TGFβ | 1,981 (1,043-3,899) |
1,179# (820.70-2,010) |
2,590 (1,261-4,745) |
| IL-5 | 1.36* (0.25-3.39) |
3.39# (2.61-6.35) |
2.43 (1.62-3.05) |
| IL-15 | 19.50‡ (13.48-28.99) |
20.80 (15.14-30.88) |
19.50 (14.16-24.65) |
| IL-17 | 0.35‡* (0.35-0.35) |
0.48# (0.35-3.24) |
3.28 (1.00-6.145) |
*
p value < 0.05 when comparing ASD GI with ASD no GI
#
p value < 0.05 when comparing ASD GI with TD
‡
p value < 0.05 when comparing ASD no GI with TD