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. Author manuscript; available in PMC: 2019 May 14.
Published in final edited form as: Cancer Cell. 2018 Apr 26;33(5):817–828.e7. doi: 10.1016/j.ccell.2018.03.026

Figure 2. Experimental validation of RNA editing events with peptide support at the RNA level.

Figure 2

(A) The relative expression (top) and the editing level changes (bottom) after transfection of wild-type ADAR enzymes (ADAR1/2 WT) and catalytically-inactive ADAR enzymes (ADAR1/2 MUT), GFP serves as negative control. Error bars denote ± SD. (B) ADAR-perturbed RNA-seq experiment. The editing levels of the six RNA editing sites with sufficient coverage (×10) in different perturbed conditions, and GFP, mock and RISC_free served as negative controls. See also Figure S2, Figure S3.