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. Author manuscript; available in PMC: 2019 May 15.
Published in final edited form as: Acc Chem Res. 2018 Apr 19;51(5):1220–1228. doi: 10.1021/acs.accounts.8b00048

Figure 4.

Figure 4

Mimicry of GB1 by heterogeneous backbones. (A) Sequence and crystal structure (PDB 2QMT) of wild-type GB1. (B) Some backbone modifications made to GB1, grouped by secondary structure context. All panels are from published crystal structures of GB1 variants (PDB: 5HFY, 5HI1, 4OZB, 4OZC, 4KGR, 4KGS, 4KGT), except data for the PEG-modified loop (from a molecular dynamics simulation) and the γcyc-modified sheet (from the NMR structure of a hairpin peptide).