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. 2018 May 15;8:7560. doi: 10.1038/s41598-018-25578-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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We proposed a set of 25 features to quantitatively characterize miRNA hairpins. We divided a model hairpin into three regions: the mature5p arm, mature3p arm and the interarm region. Each of the regions, as well as the whole hairpin, was characterized by its length and nucleotide content. Additionally, the hairpin is characterized by its free energy, number of short (<4 nt) and long loops (> = 4), the overhang and the length of the terminal loop. Hairpin_FE is the free energy calculated with RNAfold from the ViennaRNA Package. Overhang is the difference between number of unpaired nucleotides at the stem of the hairpin. Positive values indicate 5′ overhang while negative ones 3′ overhang.