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. 2018 May 15;8:7546. doi: 10.1038/s41598-018-25774-1

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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CENP-F^−/− cardiomyocytes have a disorganized z-disc structure compared to wild type cardiomyocytes. Individual slices of z-stack images in wild type cardiomyoctes show distinct z-disc staining with anti-alpha-actinin antibody (a,b). In CENP-F^−/− cardiomyocytes, alpha-actinin staining is not sharp/distinct. Additionally, z-discs are widened and severely disintegrated (c,d). This is in agreement with quantification of z-disc width conducted on TEM images (see Supplementary Fig. 4) All images are adjusted at the same brightness and contrast levels. Images are in greyscale for proper comparison of image quality. Scale bars: (a) 20 um; (b) 10 um; (c) 20 um; (d) 10 um.