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. 2018 Apr;30(2):197–208. doi: 10.21147/j.issn.1000-9604.2018.02.03

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Effect of 5-Fu/oxaliplatin (OX) on dendritic cell (DC) phenotypes. The murine myeloid-derived DCs were cultured in vitro, and Toll-like receptor 3 (TLR3), TLR7/8, 500 μg/mL 5-Fu and/or 10 μg/mL oxaliplatin were added at the last 48 h. Flow cytometry was used to detect the phenotypic expression of DCs in each group. imDCs: immature DCs, no TLR ligand and/or chemotherapeutic drugs were added; mDC: mature DCs, combined TLR ligands were added. Data are obtained from three independent experiments and represented as . *, P<0.05; **, P<0.01; ns, no significance.

Inline graphic — Effect of 5-Fu/oxaliplatin (OX) on dendritic cell (DC) phenotypes. The murine myeloid-derived DCs were cultured in vitro, and Toll-like receptor 3 (TLR3), TLR7/8, 500 μg/mL 5-Fu and/or 10 μg/mL oxaliplatin were added at the last 48 h. Flow cytometry was used to detect the phenotypic expression of DCs in each group. imDCs: immature DCs, no TLR ligand and/or chemotherapeutic drugs were added; mDC: mature DCs, combined TLR ligands were added. Data are obtained from three independent experiments and represented as . *, P<0.05; **, P<0.01; ns, no significance.