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. 2018 Apr;30(2):197–208. doi: 10.21147/j.issn.1000-9604.2018.02.03

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The specific activation of lymphocytes by 5-Fu/oxaliplatin in vivo. When the volume of the subcutaneous tumor reached 500 mm³, 50 mg/kg 5-Fu and/or 5 mg/kg oxaliplatin were injected in mice. The spleens, tumor tissues and draining lymph nodes were removed 5 d following the injection. The tumor infiltrating leukocytes, splenocytes and lymph node cells were co-cultured with nonviable MC38 cells for 16 h. Enzyme-linked immunosorbent assay (ELISA) was used to detect interferon-γ (IFN-γ) secretion. (A) Secretion level of IFN-γ from tumor infiltrating leukocytes; (B) Secretion level of IFN-γ from splenocytes; (C) Secretion level of IFN-γ from lymph node cells. The data are obtained from three independent experiments and presented as . *, P<0.05; **, P<0.01; ***, P<0.001; ns, no significance.

Inline graphic — The specific activation of lymphocytes by 5-Fu/oxaliplatin in vivo. When the volume of the subcutaneous tumor reached 500 mm³, 50 mg/kg 5-Fu and/or 5 mg/kg oxaliplatin were injected in mice. The spleens, tumor tissues and draining lymph nodes were removed 5 d following the injection. The tumor infiltrating leukocytes, splenocytes and lymph node cells were co-cultured with nonviable MC38 cells for 16 h. Enzyme-linked immunosorbent assay (ELISA) was used to detect interferon-γ (IFN-γ) secretion. (A) Secretion level of IFN-γ from tumor infiltrating leukocytes; (B) Secretion level of IFN-γ from splenocytes; (C) Secretion level of IFN-γ from lymph node cells. The data are obtained from three independent experiments and presented as . *, P<0.05; **, P<0.01; ***, P<0.001; ns, no significance.