3.

Univariate analyses of prognostic factors for recurrence and decreased survival of ypT0 patients (N=59)

Variables	Total	5-year RFS				5-year OS
		n	%*	P		n	%	P
Sex				0.462				0.752
Male	38	33	80.2			35	88.9
Female	21	17	77.9			19	86.2
Age (year)				0.459				0.535
<60	39	32	76.7			35	85.5
≥60	20	18	84.4			19	92.9
Distance from anal verge (cm)				0.408				0.249
≤5	45	37	76.8			40	85.0
>5	14	13	87.5			14	100
CEA (ng/mL)				0.113				0.188
≤5	40	36	86.3			38	92.6
>5	19	14	65.6			16	77.4
T status before treatment				0.423				0.246
cT2	3	3	100			2	66.7
cT3–4	56	47	78.2			52	89.6
N status before treatment				0.458				0.948
cN–	11	10	90.9			10	88.9
cN+	48	40	75.9			44	87.7
Treatment regimens before surgery				0.940				0.456
Radiotherapy and capecitabine	26	23	80.8			24	85.2
Radiotherapy and capecitabine 　with oxaliplatin	33	27	79.3			30	89.8
Interval between NCRT and surgery (weeks)				0.669				0.038
≤8	34	29	81.8			33	96.2
>8	25	21	74.7			21	73.7
Type of surgery				0.596				0.337
APR	34	28	78.2			30	83.9
LAR	25	22	81.8			24	94.1
Laparoscopic vs. open surgery				0.759				0.556
Fully laparoscopic	35	30	73.7			32	82.6
Open from the beginning	24	20	82.4			22	90.9
Number of LN retrieval				0.475				0.332
<12	28	22	75.4			24	83.6
≥12	31	28	87.3			30	96.6
ypN category				0.014				0.032
N–	51	45	82.7			48	90.9
N+	8	5	62.5			6	70.0
Perioperative BT				<0.001				0.037
No	49	46	90.7			47	94.7
Yes	10	4	40.0			7	68.6
Table 3 (continued)