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. 2018 May 15;8:7601. doi: 10.1038/s41598-018-25856-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The AAV-mediated induction of IL-10 reduces CAWS-induced vascular inflammation and fibrosis Mice were treated intraperitoneally with CAWS or vehicle, 2 weeks after the injection of AAV-GFP (control) or AAV-IL-10. Heart sections were obtained at day 28 after CAWS or vehicle treatment and stained with HE, EVG, MT, and SR. (A,B) Representative images of the aortic root and coronary artery are shown. (C) The fibrotic area of the aortic root and coronary artery was quantified (n = 3–4). Data are expressed as the mean ± SEM. *p < 0.05.