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. 2018 Feb 9;45(3):443–456. doi: 10.1007/s10928-018-9574-0

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 5 — Results for Scenario 1—Predicted plasma concentration of amlodipine (AML) (a) and systolic blood pressure (b) using a physiologically-based pharmacokinetic (PBPK)/pharmacodynamic (PD) model for a ritonavir (RTV)-amlodipine once daily (QD) dosage regimen with (green line) and without (pink line) amlodipine dose adjustment (Color figure online)