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. 2018 Feb 10;45(3):431–442. doi: 10.1007/s10928-018-9579-8

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 1 — Structural models for anthracycline and troponin T (K-PD) and trastuzumab and LVEF (PK-PD), K_e = elimination rate constant, A_ant = amount of anthracyclines, C_eff = the concentration in the effect compartment, K_rec = recovery rate constant, T_1/2rec = recovery half-life