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. 2018 Feb 10;45(3):431–442. doi: 10.1007/s10928-018-9579-8

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 4 — Panels of individual plots for observed (solid line) and individual predicted (dotted line) left ventricular ejection fractions (LVEFs) over time for four different patients. Vertical dashes represent the trastuzumab administrations. a Patient with maximum troponin T values in the higher range, relatively high baseline and a significant decline in LVEF value. b Patient with lower maximum concentration of troponin T, normal baseline and no significant decline in LVEF. c Patient with maximum troponin T values in the higher range, relatively low LVEF baseline and a significant decline in LVEF. d Patient with maximum troponin T values in the lower range, relatively high LVEF baseline and no significant decline in LVEF