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. 2018 May 15;8:7569. doi: 10.1038/s41598-018-25853-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Homotypic endothelial TNTs mediate Ca²⁺ propagation. Fluo-4 loaded HUVECs were mechanically stimulated (time 0 secs: fine arrow) with a glass pipette. An increase in intracellular Ca²⁺ is shown by the change in fluorescence intensity in the stimulated cell (time 14 secs). Ca²⁺ is propagated along a TNT (60 secs: thick arrow) and into the connecting cell (time 106 secs). Unconnected cells (arrowheads) do not respond. Scale bar 50 μm.