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. 2018 May 9;9:1040. doi: 10.3389/fimmu.2018.01040

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Copyright © 2018 Zhang, Zhu, Xu, Liu, Qiu, Li, Li, He, Zhou, Bai and Zhi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Bacteroides fragilis ZY-312 improves antibiotic-associated diarrhea (AAD)-related gastrointestinal symptom. (A) Experimental design schematic of different treatments in AAD rats. Rats were pretreated with antibiotic mixtures for 7 days, followed by bacterial treatment. During the treatment period (day 8–14), rats were gavaged with normal saline, ZY-312 [10⁷, 10⁸, and 10⁹ colony-forming units (CFU)/day], Bifico (70 mg/day), or Bifico (70 mg/day) combined with ZY-312 (10⁸ CFU). (B–D) Fecal consistency scores, fecal water content, and 120-min stool weight of rats in each group from day 8 to day 17 were shown. n = 16/group. Repeated measures ANOVA, *P < 0.05 and **P < 0.01 versus AAD group.