Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 May 9;9:1040. doi: 10.3389/fimmu.2018.01040

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2018 Zhang, Zhu, Xu, Liu, Qiu, Li, Li, He, Zhou, Bai and Zhi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Schematic of the therapeutic role of Bacteroides fragilis ZY-312 in AAD symptom. Antibiotic-associated diarrhea (AAD) rats exhibit dysbiosis of the gut microbiota, with overgrowth of some pathogenic bacteria and then resulting in defective gastrointestinal integrity and improper epithelial organization with low aquaporins, aberrant tight junction proteins, and a decreased number of mucus-filled goblet cells. Treatment of AAD rats with B. fragilis ZY-312 alters the composition of the gut microbiota, with promotion of commensal A. muciniphila growth, and subsequently remodeling of the colonic epithelium by improving enterocyte monolayer integrity, increasing mucus layer thickness, and water transport in rats.