Fig. 6.

The proportions of Purkinje cells with different firing patterns are changed in EAE; this change is normalized by fusion with BM-derived cells. a Different percentages of cells with tonic, trimodal and irregular firing patterns recorded in EGFP-negative and EGFP-positive Purkinje cells (fused with BM-derived cells) in EAE-mice, and in Purkinje cells from control animals [χ²(4, n = 58) = 12.42, p = 0.0145]. b Locations of recorded cells, colour-coded according to the type of firing observed, on a schematic drawing of a sagittal slice of mouse cerebellum. For a few recordings (circles next to the drawing) there was no information about their location. Numbers indicate different lobules. c Left, fraction of time spent by trimodally firing cells in each of three modes, tonic, burst and quiet. EGFP-negative cells spend more time in the tonic mode than EGFP-positive cells or cells from control animals (*p < 0.05; 2-way ANOVA, Holm-Sidak’s multiple comparison test); Right, box plot of mean durations of tonic periods in trimodally firing cells. Tonic periods are longer in EGFP-negative cells (*p < 0.05; ANOVA followed by Holm-Sidak’s multiple comparison test). Box and whisker plots show median ± quartiles (box), min/max (whiskers). n values are depicted within graph bars