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. 2018 May 9;9:1020. doi: 10.3389/fimmu.2018.01020

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Copyright © 2018 Montero-Herradón, García-Ceca and Zapata.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Presence of AIRE⁺ cells and Cld3,4⁺ cells in fetal, postnatal, and adult wild type (WT) and EphB-deficient thymi. (A) Semi-quantitative analysis of AIRE⁺ cells reveals that mutant thymi have significantly lower numbers of these cells at all studied stages. (B) Dot plots show the expression of Cld3,4^hiSSEA1⁺ medullary TECs progenitor cells in both WT and EphB-mutant thymi at E14.5 and E17.5, indicating their frequencies. (C) Comparative analysis of the proportions of Cld3,4^hiSSEA1⁺ cells in WT and EphB-deficient thymi at E14.5 and E17.5. (D) Semi-quantitative analysis of the Cld3,4^hi expression in WT and mutant thymi at 7PN. The significance of the Student’s t-test probability is indicated: **p ≤ 0.01; ***p ≤ 0.005; and ^##p ≤ 0.01 between mutants; ns, non-significant.