Fig. 1.

Methodological sequence for the estimation of brain properties. First, T1-weighted anatomical images were partitioned into two segments including the overall cortex and white matter of the brain, respectively. Second, the cortical segment was further partitioned into 180 regions per hemisphere based on the multi-modal parcellation scheme provided by the Human Connectome Project. Third, both segments and the cortical brain regions were linearly transformed into the native space of the diffusion-weighted NODDI images. Fourth, mean values of different macrostructural and microstructural measures (volume estimates and NODDI coefficients) were computed for the overall cortex and white matter using the respective segments. Fifth, at the level of single brain regions, volume estimates and NODDI coefficients from homotopic brain regions were averaged across both hemispheres resulting in 180 mean values for each macrostructural and microstructural measure, respectively