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. 2018 May 9;12:314. doi: 10.3389/fnins.2018.00314

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Copyright © 2018 Zhang, Zhong, Qi, Li, Cheng, Liu, Liu and Le.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Protein levels of β-secretase and components of γ-secretase in the hippocampus and cortex after acute hypoxia. Protein level of component of γ-secretase, Anterior pharynx-defective 1 (APH-1α), was increased significantly in the hippocampus and cortex of hypoxic mice (G,H). β-secretase (BACE1) (A,B), presenilin1 (PS1) (C,D), presenilin enhancer 2 (PEN2) (E,F) and nicastrin (NCSTN) (I,J) showed unchanged levels between hypoxic and normoxic mice. n = 5 mice in each group. *p < 0.05, **p < 0.01, ***p < 0.001, by two-way ANOVA with Tukey's multiple comparisons test.