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. 2018 May 9;12:314. doi: 10.3389/fnins.2018.00314

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Copyright © 2018 Zhang, Zhong, Qi, Li, Cheng, Liu, Liu and Le.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Immunoflourescent staining of phosphorylated tau (p-tau) T231 in the mouse hippocampus and cortex after acute hypoxia. The p-tau T231 staining was increased significantly in the hippocampus and cortex of hypoxic mice when compared to normoxic mice (A). Integrated density of p-tau T231 staining was analyzed (B). Left scale bar: 50 μm, right scale bar: 20 μm, n = 3 mice in each group. Data were the mean ± SEM values. **p < 0.01, ***p < 0.001, by two-way ANOVA with Tukey's multiple comparisons test.