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. 2018 May 9;12:314. doi: 10.3389/fnins.2018.00314

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Copyright © 2018 Zhang, Zhong, Qi, Li, Cheng, Liu, Liu and Le.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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mRNA levels of cytokines and chemokines were detected by real-time PCR in the hippocampus and cortex after acute hypoxic treatment. M1 marker cluster of differentiation 86 (CD86) (A), pro-inflammatory cytokines interleukin-6 (IL-6) (C) and tumor necrosis factor-α (TNF-α) (D), chemokines C-C motif ligand 2 (CCL2) (G) and CCL3 (H) were increased in the hypoxic mice whereas M2 marker CD206 (B), anti-inflammatory cytokines IL-4 (E) and IL-10 (F) were decreased in the hypoxic mice. n = 4 mice in each group. *p < 0.05, **p < 0.01, ***p < 0.001, by two-way ANOVA with Tukey's multiple comparisons test.