Fig. 5.

Comparison of new breakpoint and mutation rates. Each graph shows the accumulation rate of new breakpoints per sequence per nucleotide per day (blue lines), new mutations per sequence per nucleotide per day (red lines), and log-scale viral loads (green lines) in both half genomes over time for all nine participants. Upper VL detection limit is 750,000 copies/ml. The gray vertical line in CH0200 3′ half highlights the time point at which a superinfecting T/F was observed. The sequences from the last time point (day 432) in CH0654 were excluded from the analysis due to the initiation of ART at day 112