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. 2018 May 15;8:7593. doi: 10.1038/s41598-018-25879-7

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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IL-36γ is significantly associated with ICC regardless of VMB after adjusting for age, BMI, ethnicity, and Lactobacillus dominance or Sneathia presence. β-coefficients of immune mediators that were not associated with (A) or associated with Lactobacillus dominance (defined as ≥80% relative abundance) (B,C). β-coefficients of immune mediators that were associated with Sneathia presence (defined as ≥0.01% relative abundance) (D,E). Dots indicate β-coefficients of linear regression analysis; error bars represent standard error (SE). Red and blue dots indicate positive or negative associations, respectively, that were significant compared to Ctrl HPV− after adjusting for covariates (P < 0.05). Venn diagram showing relations between VMB composition and associations of immune mediators with ICC and VMB composition (F).